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| VOLUME 84 | ISSUE 11 |
PAGE 748
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| Stochastic bistable kinetics of gene transcription during the cell cycle |
V. P. Zhdanov
Department of Applied Physics, Chalmers University of Technology, S-412 96 Göteborg, Sweden
Boreskov Institute of Catalysis RAS, 630090 Novosibirsk, Russia
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PACS: 05.40.-a, 87.16.-b
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Abstract
The positive feedback between messenger ribonucleic acid (mRNA)
and regulatory-protein production may result in bistability of
gene transcription. If in addition the mRNA and/or protein numbers
in a cell are low, one can observe stochastic transcriptional
``bursts" provided that the intracellular conditions are steady. We
present Monte Carlo simulations showing what may happen with the
bursts under transient conditions during the cell cycle.
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