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| VOLUME 85 | ISSUE 6 |
PAGE 360
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| The effect of mRNA diffusion on stochastic bursts in gene transcription |
V. P. Zhdanov
Department of Applied Physics, Chalmers University of Technology, S-41296 Göteborg, Sweden
Boreskov Institute of Catalysis RAS, 630090 Novosibirsk, Russia
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PACS: 05.40.-a, 87.16.-b
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Abstract
The positive feedback between messenger ribonucleic acid (mRNA)
and regulatory-protein production may result in bistability and
stochastic ``bursts" in gene transcription. The temporal kinetics
of such bursts have already been simulated in detail. We (i) show
that the applicability of the temporal models may be limited due
to relatively slow mRNA and/or protein diffusion and (ii) present
the first 3D Monte-Carlo simulations indicating that with explicit
mRNA diffusion the bursts may be much more irregular, the periods
between bursts may be much shorter, and, depending on the
circumstances, the burst window may be reduced or extended.
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