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| VOLUME 86 | ISSUE 7 |
PAGE 563
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| Oscillatory kinetics of gene transcription during the cellular growth |
V. P. Zhdanov
Department of Applied Physics, Chalmers University of Technology, S-412 96 Göteborg, Sweden
Boreskov Institute of Catalysis Siberian reg., RAS, 630090 Novosibirsk, Russia
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PACS: 05.40.-a, 87.16.-b
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Abstract
The negative feedback between mRNA and regulatory-protein
production may result in oscillations in the kinetics of
gene transcription. If the mRNA and/or protein number
are low, the oscillations may be irregular.
We present mean-field calculations and Monte-Carlo simulations
showing evolution of such oscillations during the cellular
growth and division. The oscillations are found to be fairly
stable with respect to the cellular growth.
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