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| VOLUME 88 | ISSUE 4 |
PAGE 321
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| Amplification of kinetic oscillations in gene expression |
V. P. Zhdanov
Department of Applied Physics, Chalmers University of Technology, S-412 96 Göteborg, Sweden
Boreskov Institute of Catalysis, Siberian Branch RAS, 630090 Novosibirsk, Russia
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PACS: 05.40.-a, 87.16.-b
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Abstract
Because of the feedbacks between the DNA transcription and mRNA
translation, the gene expression in cells may exhibit bistability
and oscillations. The deterministic and stochastic calculations
presented illustrate how the bistable kinetics of expression of
one gene in a cell can be influenced by kinetic oscillations in
expression of another gene. Due to stability of the states of the
bistable kinetics of gene 1 and relatively small difference
between the maximum and minimum protein amounts during
oscillations of gene 2, the induced oscillations of gene 1 are
found to typically be related either to the low- or high-reactive
state of this gene. The quality of the induced oscillations may be
appreciably better than that of inducing oscillations. This means
that gene 1 can serve as an amplifier of kinetic oscillations of
gene 2.
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